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GPX4-IN-6

CAS No. 2922824-07-3

GPX4-IN-6( —— )

Catalog No. M37107 CAS No. 2922824-07-3

GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 67 In Stock
5MG 61 In Stock
10MG 92 In Stock
25MG 180 In Stock
50MG 276 In Stock
100MG 445 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    GPX4-IN-6
  • Note
    Research use only, not for human use.
  • Brief Description
    GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.
  • Description
    GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM.GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) .
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GPX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2922824-07-3
  • Formula Weight
    426.23
  • Molecular Formula
    C18H17BrFNO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (117.31 mM; Ultrasonic )
  • SMILES
    O=C(N(C1=CC=C2OCCOC2=C1)C3=CC(OC)=C(F)C(OC)=C3)CBr
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059.
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