ML406 ( ML406; ML-406; ML 406 )

Catalog No. M15926 CAS No. 774589-47-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ML406
Note

Research use only, not for human use.
Brief Description

ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity.
Description

ML406 is a small molecule Mtb bioA (DAPA synthase) enzyme inhibitor (IC50=30 nM) that shows anti-tubercular activity, dispalys >100-fold selectivity over bioD; exhibits WT M. tb (H37Rv) growth inhibition without biotin with an IC50 of 3.2 uM.
Synonyms

ML406; ML-406; ML 406
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

774589-47-8
Formula Weight

352.39
Molecular Formula

C20H20N2O4
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C1=CC=C(N2CCN(C(C3=CC=C(OCO4)C4=C3)=O)CC2)C=C1)=O
Chemical Name

1-(4-(4-(Benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethanone

1. Casalena D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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