ML390( —— )

Catalog No. M22425 CAS No. 2029049-79-2

ML390 exerts its potent differentiation effect on multiple leukemia models.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

ML390
Note

Research use only, not for human use.
Brief Description

ML390 exerts its potent differentiation effect on multiple leukemia models.
Description

ML390 exerts its potent differentiation effect on multiple leukemia models.
In Vitro

ML390 is active with an ED50 of ~2 μM in murine and human AML cell lines. In vitro, treatment of Lys-GFP-ER-HoxA9 cells with ML390 for 48 hr inhibits DHODH activity, leading to the dramatic (>500-fold) accumulation of the upstream metabolite DHO and the depletion of uridine and other downstream metabolites.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

2029049-79-2
Formula Weight

406.4
Molecular Formula

C21H21F3N2O3
Purity

>98% (HPLC)
Solubility

DMSO:27 mg/mL (66.44 mM)
SMILES

FC(F)(F)Oc1ccc(cc1)C(=O)NCCC(=O)N[C@@H]1CCCc2ccccc12
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Sykes DB et al. Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia. National Center for Biotechnology Information (US); 2010-2013 Dec 15.

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