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DUPA
CAS No. 302941-52-2
DUPA( (2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid | N,N''-Carbonylbis[L-glutamic acid] )
Catalog No. M27072 CAS No. 302941-52-2
DUPA is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 33 | In Stock |
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| 10MG | 55 | In Stock |
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| 25MG | 101 | In Stock |
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| 50MG | 166 | In Stock |
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| 100MG | 254 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDUPA
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NoteResearch use only, not for human use.
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Brief DescriptionDUPA is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
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DescriptionDUPA is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.(In Vitro):After binding to a DUPA-drug conjugate, PSMA internalizes, unloads the conjugate, and returns to the surface.(In Vivo):As determined by loss of body weight and death of treated mice,DUPA-indenoisoquinoline conjugate induces a complete cessation of tumor growth with no toxicity.
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In VitroDUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of prostate-specific membrane antigen (PSMA) expressing prostate cancer. The DUPA-indenoisoquinoline conjugate exhibits an IC50 in the low nanomolar range in 22RV1 cell cultures.
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In VivoThe DUPA-indenoisoquinoline conjugate induces a complete cessation of tumor growth with no toxicity, as determined by loss of body weight and death of treated mice.
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Synonyms(2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid | N,N''-Carbonylbis[L-glutamic acid]
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PathwayOthers
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TargetOther Targets
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Recptor20S proteasome
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Research Area——
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Indication——
Chemical Information
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CAS Number302941-52-2
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Formula Weight320.254
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Molecular FormulaC11H16N2O9
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 300 mg/mL (936.77 mM)
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SMILES[H][C@@](CCC(O)=O)(NC(=O)N[C@@]([H])(CCC(O)=O)C(O)=O)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Encouse B Golden, et al. Green Tea Polyphenols Block the Anticancer Effects of Bortezomib and Other Boronic Acid-Based Proteasome Inhibitors. Blood. 2009 Jun 4;113(23):5927-37.
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