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ML355
CAS No. 1532593-30-8
ML355( ML355 | ML 355 | ML-355 )
Catalog No. M17333 CAS No. 1532593-30-8
ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 58 | In Stock |
|
| 5MG | 93 | In Stock |
|
| 10MG | 147 | In Stock |
|
| 25MG | 299 | In Stock |
|
| 50MG | 494 | In Stock |
|
| 100MG | 710 | In Stock |
|
| 500MG | 1467 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML355
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NoteResearch use only, not for human use.
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Brief DescriptionML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
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DescriptionML355 is a potent and selective inhibitor of human 12-lipoxygenase.
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In VitroML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.
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In VivoML355 (1.88-30 mg/kg; i.g.; 2 times per day for two days) strongly inhibits the thrombus formation in mice at higher dose compared to WT controls. Animal Model:C57BL/6 mice Dosage:1.88, 3.75, 7.5, 15, 30 mg/kg Administration:Oral gavage; 2 times per day for two days Result:The thrombus formation in mice was strongly inhibited by higher doses of ML355.
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SynonymsML355 | ML 355 | ML-355
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PathwayOthers
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TargetOther Targets
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Recptor12-Lipoxygenase
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Research AreaInflammation/Immunology|Neurological Disease
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Indication——
Chemical Information
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CAS Number1532593-30-8
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Formula Weight441.52
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Molecular FormulaC21H19N3O4S2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 42 mg/mL. 95.13 mM
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SMILESCOC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4S3
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Chemical NameN-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Luci DK, et al. J Med Chem. 2014 Jan 23;57(2):495-506.
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