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ML324
CAS No. 1222800-79-4
ML324( ML-324 )
Catalog No. M10846 CAS No. 1222800-79-4
ML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 117 | In Stock |
|
| 50MG | 209 | In Stock |
|
| 100MG | 375 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameML324
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NoteResearch use only, not for human use.
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Brief DescriptionML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E.
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DescriptionML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E, shows no activity against LSD1 (>100-fold selectivity); causes depression-like phenotype even in absence of stress exposure, which is associated with an increase in transcriptionally repressive epigenetic marks H3K9me2/me3 in nucleus accumbens (NAc); blocks TNF-α-mediated neutrophil adhesion, reduces TNF-α-induced ICAM1 protein expression in cerebral microvessels.
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In VitroML324 produces a significant reduction in Aa-LPS-induced osteoclastogenesis in osteoclast progenitors.
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In Vivo——
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SynonymsML-324
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorJMJD2
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number1222800-79-4
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Formula Weight349.4262
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Molecular FormulaC21H23N3O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 33 mg/mL
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SMILESO=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1
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Chemical NameBenzamide, N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rai G, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Pathak SS, et al. Neuropsychopharmacology. 2017 Mar;42(4):854-863.
3. Choi JY, et al. Sci Rep. 2017 Mar 22;7:45005.
4. Ishiguro K, et al. Clin Immunol. 2017 Jul;180:120-127.
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