ML281( ML-281 | ML-281 | ML281 )

Catalog No. M17278 CAS No. 1404437-62-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

ML281
Note

Research use only, not for human use.
Brief Description

ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.
Description

ML-281 is a potent ans selective STK33 inhibitor (IC50 = 14 nM). ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. ML281 is a valuable addition to small-molecule probes of STK33. v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most mutated oncogene, and KRAS mutations have been found in up to 20% of all human tumors. STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers.
In Vitro

Cell Viability Assay Cell Line:NCI-H446 cells Concentration:10 μM Incubation Time:72 hours Result:Suppressed cell viability of NCI-H446 cells.
In Vivo

——
Synonyms

ML-281 | ML-281 | ML281
Pathway

Others
Target

Other Targets
Recptor

STK33
Research Area

Cancer
Indication

——

CAS Number

1404437-62-2
Formula Weight

389.47
Molecular Formula

C22H19N3O2S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 30 mg/mL. 77.03 mM; H2O : < 0.1 mg/mL
SMILES

O=C(c1cccs1)Nc1ccc(C(C)C)cc1c1nc2c(cccc2)[nH]c1=O
Chemical Name

N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide

1.Spoonamore J et al. National Center for Biotechnology Information (US); 2010-2011 Dec 16.

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