ML-323

CAS No. 1572414-83-5

ML-323 ( ML323;ML 323 )

Catalog No. M12245 CAS No. 1572414-83-5

A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 47 In Stock
10MG 69 In Stock
25MG 92 In Stock
50MG 142 In Stock
100MG 215 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    ML-323
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.
  • Description
    A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM; displays >1,500-fold selectivity versus USP2, USP5, USP7, USP8, and USP46/UAF1; potentiates the cytotoxicity of cisplatin and increases endogenous monoubiquitination levels of both PCNA and FANCD2, two known cellular targets of USP1/UAF1; possesses a promising in vitro ADME profile.
  • Synonyms
    ML323;ML 323
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    USP1-UAF1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1572414-83-5
  • Formula Weight
    384.48
  • Molecular Formula
    C23H24N6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 49 mg/mL
  • SMILES
    CC1=CN=C(C2=CC=CC=C2C(C)C)N=C1NCC3=CC=C(N4N=NC=C4)C=C3
  • Chemical Name
    N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liang Q, et al. Nat Chem Biol. 2014 Apr;10(4):298-304.
2. Dexheimer TS, et al. J Med Chem. 2014 Oct 9;57(19):8099-110.
3. Sourisseau T, et al. Cell Cycle. 2016;15(2):295-302. doi: 10.1080/15384101.2015.1120918.
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