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ML-323
CAS No. 1572414-83-5
ML-323 ( ML323;ML 323 )
Catalog No. M12245 CAS No. 1572414-83-5
A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 47 | In Stock |
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| 10MG | 69 | In Stock |
|
| 25MG | 92 | In Stock |
|
| 50MG | 142 | In Stock |
|
| 100MG | 215 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameML-323
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.
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DescriptionA potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM; displays >1,500-fold selectivity versus USP2, USP5, USP7, USP8, and USP46/UAF1; potentiates the cytotoxicity of cisplatin and increases endogenous monoubiquitination levels of both PCNA and FANCD2, two known cellular targets of USP1/UAF1; possesses a promising in vitro ADME profile.
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SynonymsML323;ML 323
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorUSP1-UAF1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1572414-83-5
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Formula Weight384.48
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Molecular FormulaC23H24N6
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 49 mg/mL
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SMILESCC1=CN=C(C2=CC=CC=C2C(C)C)N=C1NCC3=CC=C(N4N=NC=C4)C=C3
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Chemical NameN-(4-(1H-1,2,3-triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liang Q, et al. Nat Chem Biol. 2014 Apr;10(4):298-304.
2. Dexheimer TS, et al. J Med Chem. 2014 Oct 9;57(19):8099-110.
3. Sourisseau T, et al. Cell Cycle. 2016;15(2):295-302. doi: 10.1080/15384101.2015.1120918.
2. Dexheimer TS, et al. J Med Chem. 2014 Oct 9;57(19):8099-110.
3. Sourisseau T, et al. Cell Cycle. 2016;15(2):295-302. doi: 10.1080/15384101.2015.1120918.
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