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FT-827

CAS No. 1959537-86-0

FT-827( FT827 | FT 827 )

Catalog No. M13071 CAS No. 1959537-86-0

A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    FT-827
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).
  • Description
    A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain); modifies the catalytic Cys223 of USP7 and inhibits the enzyme with kinact/Ki of 66 M-1s-1, display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    FT827 | FT 827
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1959537-86-0
  • Formula Weight
    548.618
  • Molecular Formula
    C27H28N6O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 125 mg/mL 227.85 mM
  • SMILES
    O=C(N1CCC(O)(CN2C=NC(N(C)N=C3)=C3C2=O)CC1)C(C=C4)=CC=C4C5=CC=CC=C5NS(C=C)(=O)=O
  • Chemical Name
    N-(4'-(4-hydroxy-4-((1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)methyl)piperidine-1-carbonyl)-[1,1'-biphenyl]-2-yl)ethenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.
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