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Home - Products - Proteasome/Ubiquitin - p97 - ML-241 hydrochloride

ML-241 hydrochloride

CAS No. 2070015-13-1

ML-241 hydrochloride ( ML241 hydrochloride;ML 241 hydrochloride )

Catalog No. M13221 CAS No. 2070015-13-1

ML241 Hcl is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML-241 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    ML241 Hcl is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM).
  • Description
    ML241 Hcl is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM); blocks degradation of p97-dependent proteasome substrate with an IC50 of 3.5 uM; induces caspases 3 and 7 and potently blocks proliferation in HCT15 and SW403 cells.
  • Synonyms
    ML241 hydrochloride;ML 241 hydrochloride
  • Pathway
    Proteasome/Ubiquitin
  • Target
    p97
  • Recptor
    p97
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    2070015-13-1
  • Formula Weight
    408.92
  • Molecular Formula
    C23H25ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 34 mg/mL
  • SMILES
    [H]Cl.C1(N2C3=CC=CC=C3OCC2)=NC(NCC4=CC=CC=C4)=C5CCCCC5=N1
  • Chemical Name
    4-Quinazolinamine, 2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydro-N-(phenylmethyl)-,hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chou TF, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Chou TF, et al. ChemMedChem. 2013 Feb;8(2):297-312.
3. Fang CJ, et al. ChemMedChem. 2015 Jan;10(1):52-6.
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