ML-148

CAS No. 451496-96-1

ML-148 ( —— )

Catalog No. M28159 CAS No. 451496-96-1

ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 170 Get Quote
10MG 267 Get Quote
25MG 483 Get Quote
50MG 698 Get Quote
100MG 972 Get Quote
500MG 1953 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    ML-148
  • Note
    Research use only, not for human use.
  • Brief Description
    ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).
  • Description
    ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostaglandin-signaling pathways.(In Vitro):ML148 (10 nM) reduces the apparent Km by half and decreases Vmax by 25%. ML148 shows selectivity with IC50s of 36000, >57500, >57500 nM for ALDH1A1, HADH2, HSD17β4, respectively.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    GPR52
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    451496-96-1
  • Formula Weight
    319.4
  • Molecular Formula
    C20H21N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C=1C=CC2=C(N=CN2C3=CC=CC(=C3)C)C1)N4CCCCC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang, C., Zhang, Y.-F., Guo, S., et al.GPR52 antagonist reduces huntingtin levels and ameliorates Huntington’s disease-related phenotypesJ. Med. Chem.64(2)941-957(2021)
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