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Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - ML-148

ML-148

CAS No. 451496-96-1

ML-148 ( —— )

Catalog No. M28159 CAS No. 451496-96-1

ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 170 Get Quote
10MG 267 Get Quote
25MG 483 Get Quote
50MG 698 Get Quote
100MG 972 Get Quote
500MG 1953 Get Quote
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Biological Information

  • Product Name
    ML-148
  • Note
    Research use only, not for human use.
  • Brief Description
    ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).
  • Description
    ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostaglandin-signaling pathways.(In Vitro):ML148 (10 nM) reduces the apparent Km by half and decreases Vmax by 25%. ML148 shows selectivity with IC50s of 36000, >57500, >57500 nM for ALDH1A1, HADH2, HSD17β4, respectively.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    GPR52
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    451496-96-1
  • Formula Weight
    319.4
  • Molecular Formula
    C20H21N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C=1C=CC2=C(N=CN2C3=CC=CC(=C3)C)C1)N4CCCCC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang, C., Zhang, Y.-F., Guo, S., et al.GPR52 antagonist reduces huntingtin levels and ameliorates Huntington’s disease-related phenotypesJ. Med. Chem.64(2)941-957(2021)
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