MKI-1

CAS No. 1190277-80-5

MKI-1( —— )

Catalog No. M35458 CAS No. 1190277-80-5

MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 122 Get Quote
5MG 187 Get Quote
10MG 302 Get Quote
25MG 495 Get Quote
50MG 802 Get Quote
100MG 1197 Get Quote
500MG 2394 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    MKI-1
  • Note
    Research use only, not for human use.
  • Brief Description
    MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM).
  • Description
    MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 of 9.9 μM, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer.
  • In Vitro
    MKI-1 (5-20 μM) inhibits the activity of MASTL in breast cancer cells.MKI-1 (100 μM, 72 h) inhibits various oncogenic properties of breast cancer cells but showed much weaker effects on the viability of normal breast cells.MKI-1 clearly reduces both serine 62-phosphorylation of c-Myc and total c-Myc, with a decrease in ENSA phosphorylation.MKI-1 (20 μM, 16 h) reduces c-Myc stability through PP2A activation in MCF7 cells.Western Blot Analysis Cell Line:MCF7 and T47D cells.Concentration:5-20 μM. Incubation Time:24 h.Result:Inhibited the phosphorylation of ENSA in MCF7 and T47D cells.Significantly inhibited the phosphorylation of ENSA in mitotic cells.
  • In Vivo
    MKI-1 (50 mg/kg, ip, twice a week) reduces tumor growth and enhances the radiosensitivity of BT549 xenograft model in response to 6 Gy irradiation compared with the control group, with no notable changes in body weight, suggesting the absence of gross toxicity in the treated mice.Animal Model:Five-week-old female BALB/c nude mice (BT549 cells).Dosage:50 mg/kg.Administration:Twice per week by intraperitoneal (i.p.) injection.Result:Reduced tumor growth.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1190277-80-5
  • Formula Weight
    302.33
  • Molecular Formula
    C18H14N4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (826.91 mM; Ultrasonic )
  • SMILES
    O=C(Nc1nc2ccccc2[nH]1)c1cccc(c1)-n1cccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ah-Young Kim, et al. MKI-1, a Novel Small-Molecule Inhibitor of MASTL, Exerts Antitumor and Radiosensitizer Activities Through PP2A Activation in Breast cancer. Front Oncol. 2020 Sep 29;10:571601.?
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