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MK2-IN-1
CAS No. 1314118-92-7
MK2-IN-1( MK2 Inhibitor )
Catalog No. M11260 CAS No. 1314118-92-7
MK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2(MK2) inhibitor with IC50 of 0.11 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameMK2-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionMK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2(MK2) inhibitor with IC50 of 0.11 uM.
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DescriptionMK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2(MK2) inhibitor with IC50 of 0.11 uM; shows excellent kinase selectivity against a broad panel of 150 protein kinases at 10 μM with only on exception of CK1γ3 >50 % inhibition; inhibits pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion; also dose dependently inhibits IL1β-stimulated MMP13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures.
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In VitroWestern Blot Analysis Cell Line:46C mouse embryonic stem cells (mESCs) Concentration:5 μM Incubation Time:0.5, 1, 2, 8 h Result:The Tfcp2l1 protein level gradually increased without a change in the Tfcp2l1 transcript level within 2 h.
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In Vivo——
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SynonymsMK2 Inhibitor
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PathwayMAPK/ERK Signaling
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TargetMAPKAPK2 (MK2)
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RecptorMAPKAPK2 (MK2)
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1314118-92-7
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Formula Weight472.966
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Molecular FormulaC27H25ClN4O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1CN(CCN1)C2=CC=C(C=C2)N(CC3=CC=CC=N3)C(=O)C4=CC=C(O4)C5=CC=C(C=C5)Cl
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Chemical Name2-Furancarboxamide, 5-(4-chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rao AU, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1068-72.
2. Huang X, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70.
3. Huang X, et al. ACS Med Chem Lett. 2011 Jun 24;2(8):632-7.
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MK2 inhibitor III
A potent, cell-permeable inhibitor of MK2 with IC50 of 8.5 nM; less potently blocks MK3 and MK5 (IC50s=210 and 81 nM, respectively).
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MK2-IN-1
MK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2(MK2) inhibitor with IC50 of 0.11 uM.
