MK-8998( CX-8998 )

Catalog No. M16815 CAS No. 953778-58-0

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HNMR

HPLC

MSDS

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Product Name

MK-8998
Note

Research use only, not for human use.
Brief Description

MK-8998 (CX-8998) is a potent and selective antagonist of the T-type calcium channel for the treatment of schizophrenia.
Description

MK-8998 (CX-8998) is a potent and selective antagonist of the T-type calcium channel for the treatment of schizophrenia.; does not block D2, 5HT2a, muscarinic, or histaminic receptors; has the potential for a substantially improved side effect profile compared with currently available atypical antipsychotics.Schizophrenia Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

CX-8998
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

Calcium Channel
Research Area

Neurological Disease
Indication

Schizophrenia

CAS Number

953778-58-0
Formula Weight

380.4040296
Molecular Formula

C20H23F3N2O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC(C)C1=CC=C(CC(N[C@H](C)C2=NC=C(OCC(F)(F)F)C=C2)=O)C=C1
Chemical Name

Benzeneacetamide, 4-(1-methylethyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl]-

1. Egan MF, et al. Hum Psychopharmacol. 2013 Mar;28(2):124-33.

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