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MK-3697
CAS No. 1224846-01-8
MK-3697( MK 3697 | MK3697 )
Catalog No. M10860 CAS No. 1224846-01-8
MK-3697 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki of 1.1 nM and IC50 of 16 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 57 | In Stock |
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| 5MG | 87 | In Stock |
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| 10MG | 110 | In Stock |
|
| 25MG | 200 | In Stock |
|
| 50MG | 332 | In Stock |
|
| 100MG | 478 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMK-3697
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NoteResearch use only, not for human use.
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Brief DescriptionMK-3697 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki of 1.1 nM and IC50 of 16 nM.
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DescriptionMK-3697 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki of 1.1 nM and IC50 of 16 nM, shows exquisite selectivity over OX1R (Ki=18 uM); MK-3697 is orally efficacious in sleep experiments across species with high OX2R occupancy and low OX1R blockade, demonstrated excellent sleep efficacy across species, and shows potential for the treatment of insomnia.Sleep Disorder Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsMK 3697 | MK3697
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PathwayGPCR/G Protein
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TargetOrexin Receptor
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RecptorOX2
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Research AreaNeurological Disease
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IndicationSleep Disorder
Chemical Information
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CAS Number1224846-01-8
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Formula Weight447.5096
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Molecular FormulaC23H21N5O3S
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Purity>98% (HPLC)
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SolubilityDMSO: 22.5 mg/mL
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SMILESCOC1=C(OC)N=C(CNC(=O)C2=CC(=NC=C2C2=NC=CS2)C2=CC(C)=CN=C2)C=C1
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Chemical Name[2,3'-Bipyridine]-4-carboxamide, N-[(5,6-dimethoxy-2-pyridinyl)methyl]-5'-methyl-5-(2-thiazolyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Roecker AJ, et al. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4884-90.
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