Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Orexin Receptor - ACT-541468

ACT-541468

CAS No. 1505484-82-1

ACT-541468( Nemorexant | ACT541468 | DORA )

Catalog No. M12099 CAS No. 1505484-82-1

A potent, selective, dual orexin receptor 1 and 2 (OX1 and OX2) antagonist with Kb of 0.52 and 0.78 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    ACT-541468
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, dual orexin receptor 1 and 2 (OX1 and OX2) antagonist with Kb of 0.52 and 0.78 nM, respectively.
  • Description
    A potent, selective, dual orexin receptor 1 and 2 (OX1 and OX2) antagonist with Kb of 0.52 and 0.78 nM, respectively; displays high selectivity over a panel of 130 central and peripheral pharmacological targets; shows potential for treatment of insomnia disorder.Sleep Disorder Phase 2 Clinical
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Nemorexant | ACT541468 | DORA
  • Pathway
    GPCR/G Protein
  • Target
    Orexin Receptor
  • Recptor
    Orexin Receptor
  • Research Area
    Neurological Disease
  • Indication
    Sleep Disorder

Chemical Information

  • CAS Number
    1505484-82-1
  • Formula Weight
    450.927
  • Molecular Formula
    C23H23ClN6O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 250 mg/mL 554.42 mM
  • SMILES
    O=C(N1[C@](C)(C2=NC3=C(C)C(Cl)=CC=C3N2)CCC1)C4=CC(OC)=CC=C4N5N=CC=N5
  • Chemical Name
    (S)-(2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Treiber A, et al. J Pharmacol Exp Ther. 2017 Sep;362(3):489-503.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Lemborexant

    An orally active, potent, selective, dual Orexin receptor OX1/2 antagonist with binding Ki of 6/3 nM, respectively.

  • Seltorexant

    A potent, selective, orally active orexin-2 receptor (OX2R) antagonist with pKi of 8.0 and 8.1 for human and rat OX2R, respectively.

  • SB-649868

    A potent, selective, orally bioavailable, dual orexin OX1/OX2R antagonist with pKi of 9.4 and 9.5 respectively.

Sign In Join Free