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WAY 163909

CAS No. 428868-32-0

WAY 163909( WAY163909 | WAY-163909 )

Catalog No. M14454 CAS No. 428868-32-0

A highly potent, subtype-selective agonist of 5-HT2C receptor with Ki of 10.5 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    WAY 163909
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent, subtype-selective agonist of 5-HT2C receptor with Ki of 10.5 nM.
  • Description
    A highly potent, subtype-selective agonist of 5-HT2C receptor with Ki of 10.5 nM, >20-fold selectivity over 5-HT2A and 5-HT2B receptor subtypes (IC50=212 and 485 nM, respectively); stimulates the mobilization of intracellular calcium in CHO cells stably expressing the human 5-HT2C with EC50 of 8 nM; produces a dose-dependent reduction in food intake in rat (ED50=2.93 mg/kg), also exhibits preclinical antipsychotic-like activity in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    WAY163909 | WAY-163909
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    428868-32-0
  • Formula Weight
    214.31
  • Molecular Formula
    C14H18N2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [H][C@]1(CCC[C@]21[H])N3CCNCC4=C3C2=CC=C4
  • Chemical Name
    (11R,15R)-7,10-diazatetracyclo[8.5.1.0^{5,16}.0^{11,15}]hexadeca-1,3,5(16)-triene

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dunlop J, et al. J Pharmacol Exp Ther. 2005 May;313(2):862-9. 2. Marquis KL, et al. J Pharmacol Exp Ther. 2007 Jan;320(1):486-96. 3. Rosenzweig-Lipson S, et al. Psychopharmacology (Berl). 2007 Jun;192(2):159-70. 4. Grauer SM, et al. Psychopharmacology (Berl). 2009 May;204(1):37-48.
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