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MK-2048
CAS No. 869901-69-9
MK-2048( MK 2048 | MK2048 )
Catalog No. M16319 CAS No. 869901-69-9
MK-2048 is a potent inhibitor of HIV-1 integrase (IN) and IN mutant R263K with IC50 of 2.6 nM and 1.5 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 211 | Get Quote |
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| 25MG | 559 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameMK-2048
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NoteResearch use only, not for human use.
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Brief DescriptionMK-2048 is a potent inhibitor of HIV-1 integrase (IN) and IN mutant R263K with IC50 of 2.6 nM and 1.5 nM, respectively.
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DescriptionMK-2048 is a potent inhibitor of HIV-1 integrase (IN) and IN mutant R263K with IC50 of 2.6 nM and 1.5 nM, respectively; inhibits subtype B and subtype C integrase activities with IC50 of 75 nM and 80 nM, respectively; inhibits S217H intasome with an IC50 of 900 nM, remains fully active against the N224H intasome with IC50 of 25 nM.,displays substantially lower dissociation rates compared with raltegravir, another integrase inhibitor.HIV Infection Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsMK 2048 | MK2048
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorIntegrase|Integrase(R263K)
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Research AreaInfection
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IndicationHIV Infection
Chemical Information
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CAS Number869901-69-9
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Formula Weight461.8784
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Molecular FormulaC21H21ClFN5O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(C(C1=C2C(O)=C3N1[C@@H](C)CN(CC)C3=O)=NN(CC4=CC=C(F)C(Cl)=C4)C2=O)NC
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Chemical NamePyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, 2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxo-, (6S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Quashie PK, et al. J Virol. 2012 Mar;86(5):2696-705.
2. Van Wesenbeeck L, et al. Antimicrob Agents Chemother. 2011 Jan;55(1):321-5.
3. Bar-Magen T, et al. J Virol. 2010 Sep;84(18):9210-6.
4. Marsden MD, et al. Antimicrob Agents Chemother. 2011 Aug;55(8):3696-702.
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