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MK-2048

CAS No. 869901-69-9

MK-2048 ( MK 2048;MK2048 )

Catalog No. M16319 CAS No. 869901-69-9

MK-2048 is a potent inhibitor of HIV-1 integrase (IN) and IN mutant R263K with IC50 of 2.6 nM and 1.5 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MK-2048
  • Note
    Research use only, not for human use.
  • Brief Description
    MK-2048 is a potent inhibitor of HIV-1 integrase (IN) and IN mutant R263K with IC50 of 2.6 nM and 1.5 nM, respectively.
  • Description
    MK-2048 is a potent inhibitor of HIV-1 integrase (IN) and IN mutant R263K with IC50 of 2.6 nM and 1.5 nM, respectively; inhibits subtype B and subtype C integrase activities with IC50 of 75 nM and 80 nM, respectively; inhibits S217H intasome with an IC50 of 900 nM, remains fully active against the N224H intasome with IC50 of 25 nM.,displays substantially lower dissociation rates compared with raltegravir, another integrase inhibitor.HIV Infection Phase 1 Clinical
  • Synonyms
    MK 2048;MK2048
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    Integrase;Integrase(R263K)
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    869901-69-9
  • Formula Weight
    461.88
  • Molecular Formula
    C21H21ClFN5O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C(C1=C2C(O)=C3N1[C@@H](C)CN(CC)C3=O)=NN(CC4=CC=C(F)C(Cl)=C4)C2=O)NC
  • Chemical Name
    Pyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, 2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxo-, (6S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Quashie PK, et al. J Virol. 2012 Mar;86(5):2696-705.
2. Van Wesenbeeck L, et al. Antimicrob Agents Chemother. 2011 Jan;55(1):321-5.
3. Bar-Magen T, et al. J Virol. 2010 Sep;84(18):9210-6.
4. Marsden MD, et al. Antimicrob Agents Chemother. 2011 Aug;55(8):3696-702.
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