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MK-0893
CAS No. 870823-12-4
MK-0893( MK0893 | MK 0893 )
Catalog No. M16326 CAS No. 870823-12-4
A potent, selective, reversible and competitive antagonist of glucagon receptor with high binding affinity (IC(=50=6.6 nM) and functional cAMP activity (IC50=15.7 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 322 | Get Quote |
|
| 50MG | 1269 | Get Quote |
|
| 100MG | 1926 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMK-0893
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, reversible and competitive antagonist of glucagon receptor with high binding affinity (IC(=50=6.6 nM) and functional cAMP activity (IC50=15.7 nM).
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DescriptionA potent, selective, reversible and competitive antagonist of glucagon receptor with high binding affinity (IC(=50=6.6 nM) and functional cAMP activity (IC50=15.7 nM); displays selectivity for glucagon receptor relative to other family B GPCRs, IC50 of 1020 nM for GIPR, 9200 nM for PAC1, and >10000 nM for GLP-1R, VPAC1, and VPAC2; blunts glucagon-induced glucose elevation in hGCGR mice and rhesus monkeys, also lowers ambient glucose levels in both acute and chronic mouse models.Diabetes Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsMK0893 | MK 0893
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PathwayGPCR/G Protein
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TargetGlucagon Receptor
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RecptorGlucagon Receptor
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number870823-12-4
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Formula Weight588.4805
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Molecular FormulaC32H27Cl2N3O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC(C1=CC=C(C=C1)C(=O)NCCC(=O)O)N2C(=CC(=N2)C3=CC(=CC(=C3)Cl)Cl)C4=CC5=C(C=C4)C=C(C=C5)OC
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Chemical Name.beta.-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xiong Y, et al. J Med Chem. 2012 Jul 12;55(13):6137-48.
2. Guan HP, et al. J Lipid Res. 2015 Nov;56(11):2183-95.
3. Jazayeri A, et al. Nature. 2016 May 12;533(7602):274-7.
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