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Survodutide
CAS No. 2805997-46-8
Survodutide( —— )
Catalog No. M36653 CAS No. 2805997-46-8
Survodutide (BI 456906) is a dual agonist of glucagon and glucagon-like peptide 1 (GLP-1) receptors (GLP Receptor) that reduces body weight in HbA1c16 diabetes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 161 | Get Quote |
|
| 5MG | 217 | Get Quote |
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| 10MG | 330 | Get Quote |
|
| 25MG | 531 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSurvodutide
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NoteResearch use only, not for human use.
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Brief DescriptionSurvodutide (BI 456906) is a dual agonist of glucagon and glucagon-like peptide 1 (GLP-1) receptors (GLP Receptor) that reduces body weight in HbA1c16 diabetes.
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DescriptionSurvodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake.
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In Vitro——
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In VivoAnimal Model:Male C57BL6/J mice pre-fed with a 60% HFD (22 weeks)Dosage:3, 10, 20, 30 nmol/kg Administration:SC; daily; 30 days Result:Dose-dependently reduced bodyweight from baseline by up to 32% at Day 28 at a dose of 30 nmol/kg.
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Synonyms——
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PathwayGPCR/G Protein
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TargetGlucagon Receptor
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RecptorGlucagon Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2805997-46-8
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Formula Weight4231.62
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Molecular FormulaC192H289N47O61
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (23.63 mM; Ultrasonic )
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tina Zimmermann, et al. BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy. Mol Metab. 2022 Dec:66:101633. ?
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