MK-0448

Research use only, not for human use.

MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM.

MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM; also demonstrates a potent effect on currents associated with other Kv1.x and Kv2.x subunits, such as Kv1.7 and Kv2.1, with IC50 of 72 and 61 nM, respectively; displays >70-fold concentration than inhibition of IKur; significantly causes prolongation of the atrial refractory period in normal anesthetized dogs.Heart Arrhythmia Phase 1 Clinical

MK0448

Cell Cycle/DNA Damage

Potassium Channel

Potassium Channel

Cardiovascular Disease

Heart Arrhythmia

875562-81-5

448.52

C24H21FN4O2S

>98% (HPLC)

——

CS(=O)(NC1=NC([C@H](C2=CC=C(F)C=C2)C(C3=CC=CN=C3)C4=CC=CN=C4)=CC=C1)=O

N-{6-[(1S)-1-(4-fluorophenyl)-2,2-di(pyridin-3-yl)ethyl]pyridin-2-yl}methanesulfon- amide

(-20℃)

With Ice Pack

≥ 2 years