Cart
sales@molnova.com
MK-0448
CAS No. 875562-81-5
MK-0448( MK0448 )
Catalog No. M16363 CAS No. 875562-81-5
MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMK-0448
-
NoteResearch use only, not for human use.
-
Brief DescriptionMK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM.
-
DescriptionMK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM; also demonstrates a potent effect on currents associated with other Kv1.x and Kv2.x subunits, such as Kv1.7 and Kv2.1, with IC50 of 72 and 61 nM, respectively; displays >70-fold concentration than inhibition of IKur; significantly causes prolongation of the atrial refractory period in normal anesthetized dogs.Heart Arrhythmia Phase 1 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsMK0448
-
PathwayCell Cycle/DNA Damage
-
TargetPotassium Channel
-
RecptorPotassium Channel
-
Research AreaCardiovascular Disease
-
IndicationHeart Arrhythmia
Chemical Information
-
CAS Number875562-81-5
-
Formula Weight448.516
-
Molecular FormulaC24H21FN4O2S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCS(=O)(NC1=NC([C@H](C2=CC=C(F)C=C2)C(C3=CC=CN=C3)C4=CC=CN=C4)=CC=C1)=O
-
Chemical NameN-{6-[(1S)-1-(4-fluorophenyl)-2,2-di(pyridin-3-yl)ethyl]pyridin-2-yl}methanesulfon- amide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Pavri BB, et al. Circ Arrhythm Electrophysiol. 2012 Dec;5(6):1193-201.
2. Loose S, et al. Front Pharmacol. 2014 Mar 4;5:26.
3. Wolkenberg SE, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1062-1069.
molnova catalog
related products
-
Amsacrine
Amsacrine (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.
-
KCC2 blocker 1
(+)-KCC2 blocker 1 is a selective blocker of KCC2 (IC50 = 0.4 μM).
-
5-Hydroxydecanoate s...
5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker with an IC50 of approximately 30 μM and a substrate for mitochondrial outer membrane acyl-CoA synthetase, possessing antioxidant properties.
