MK-0249

CAS No. 1167574-41-5

MK-0249 ( MK0249 )

Catalog No. M10571 CAS No. 1167574-41-5

MK-0249 is a novel potent, selective histamine H3 inverse agonist for the treatment of cognitive impairment with schizophrenia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MK-0249
  • Note
    Research use only, not for human use.
  • Brief Description
    MK-0249 is a novel potent, selective histamine H3 inverse agonist for the treatment of cognitive impairment with schizophrenia.
  • Description
    MK-0249 is a novel potent, selective histamine H3 inverse agonist for the treatment of cognitive impairment with schizophrenia.Sleep Disorder Phase 1 Discontinued
  • Synonyms
    MK0249
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    Neurological Disease
  • Indication
    Sleep Disorder

Chemical Information

  • CAS Number
    1167574-41-5
  • Formula Weight
    431.46
  • Molecular Formula
    C23H24F3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1N(C2=CC=C(OCCCN3CCCC3)C=C2)C(C)=NC4=C1C(C(F)(F)F)=CC=C4
  • Chemical Name
    2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)-5-(trifluoromethyl)quinazolin-4(3H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Brioni JD, et al. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.
2. James LM, et al. Psychopharmacology (Berl). 2011 Jun;215(4):643-53.
3. Zoethout RW, et al. J Psychopharmacol. 2012 Feb;26(2):292-302.
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