MK-0249 ( MK0249 )

Catalog No. M10571 CAS No. 1167574-41-5

MK-0249 is a novel potent, selective histamine H3 inverse agonist for the treatment of cognitive impairment with schizophrenia.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

MK-0249
Note

Research use only, not for human use.
Brief Description

MK-0249 is a novel potent, selective histamine H3 inverse agonist for the treatment of cognitive impairment with schizophrenia.
Description

MK-0249 is a novel potent, selective histamine H3 inverse agonist for the treatment of cognitive impairment with schizophrenia.Sleep Disorder Phase 1 Discontinued
Synonyms

MK0249
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Histamine Receptor
Research Area

Neurological Disease
Indication

Sleep Disorder

Chemical Information

CAS Number

1167574-41-5
Formula Weight

431.46
Molecular Formula

C23H24F3N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1N(C2=CC=C(OCCCN3CCCC3)C=C2)C(C)=NC4=C1C(C(F)(F)F)=CC=C4
Chemical Name

2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)-5-(trifluoromethyl)quinazolin-4(3H)-one

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Brioni JD, et al. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.
2. James LM, et al. Psychopharmacology (Berl). 2011 Jun;215(4):643-53.
3. Zoethout RW, et al. J Psychopharmacol. 2012 Feb;26(2):292-302.

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