MIDD0301( MIDD 0301 | MIDD-0301 )

Catalog No. M13489 CAS No. 2187489-08-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

MIDD0301
Note

Research use only, not for human use.
Brief Description

MIDD0301 is a potent, positive allosteric, α5β3γ2 selective, GABAA receptor (GABAAR) ligand with EC50 of 17 nM.
Description

MIDD0301 is a potent, positive allosteric, α5β3γ2 selective, GABAA receptor (GABAAR) ligand with EC50 of 17 nM, shows no significant binding at the peripheral GABAAR at 10 uM; causes amplification of GABA induced current mediated by α1-3,5β3γ2 GABAARs in the presence of MIDD0301 in automated patch clamp test; relaxes airway smooth muscle at single micromolar concentrations as demonstrated with ex vivo guinea pig tracheal rings, also attenuates airway hyperresponsiveness (AHR) in an ovalbumin murine model of asthma by oral administration, with low brain distribution; reduces lung cytokine expression of IL-17A, IL-4, and TNF-α, as wells as the number of CD4+ T cells.
In Vitro

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In Vivo

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Synonyms

MIDD 0301 | MIDD-0301
Pathway

Membrane Transporter/Ion Channel
Target

GAT
Recptor

GAT
Research Area

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Indication

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CAS Number

2187489-08-1
Formula Weight

414.234
Molecular Formula

C19H13BrFN3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (241.41 mM)
SMILES

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Chemical Name

(R)-8-bromo-6-(2-fluorophenyl)-4-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylic acid

1. Forkuo GS, et al. Mol Pharm. 2018 Apr 2. doi: 10.1021/acs.molpharmaceut.7b01013.

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