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CPP-115

CAS No. 640897-20-7

CPP-115( CPP115 )

Catalog No. M15436 CAS No. 640897-20-7

CPP-115 is an orally available, small molecule, next-generation GABA aminotransferase (GABA-AT) inhibitor with Ki of 31 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CPP-115
  • Note
    Research use only, not for human use.
  • Brief Description
    CPP-115 is an orally available, small molecule, next-generation GABA aminotransferase (GABA-AT) inhibitor with Ki of 31 uM.
  • Description
    CPP-115 is an orally available, small molecule, next-generation GABA aminotransferase (GABA-AT) inhibitor with Ki of 31 uM, without other GABAergic or off-target activities; displays superior enzyme inactivation properties compared to vigabatrin, decreases spasms in the multiple-hit rat model of infantile spasms, deonstrates high therapeutic potential for the treatment of cocaine addiction and for a variety of epilepsies.Epilepsy Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CPP115
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GAT
  • Recptor
    GAT
  • Research Area
    Neurological Disease
  • Indication
    Epilepsy

Chemical Information

  • CAS Number
    640897-20-7
  • Formula Weight
    177.151
  • Molecular Formula
    C7H9F2NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C([C@@H]1C[C@H](N)/C(C1)=C(F)/F)O
  • Chemical Name
    (1S,3S)-3-amino-4-(difluoromethylidene)cyclopentane-1-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pan Y, et al. J Med Chem. 2012 Jan 12;55(1):357-66. 2. Briggs SW, et al. Epilepsia. 2014 Jan;55(1):94-102. 3. Lee H, et al. J Am Chem Soc. 2015 Feb 25;137(7):2628-40. 4. Prescot AP, et al. Neuropsychopharmacology. 2018 Feb;43(3):646-654.
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