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MHP

CAS No. 1104874-94-3

MHP( Defensamide | methyl caprooyl tyrosinate | MHP )

Catalog No. M17816 CAS No. 1104874-94-3

MHP is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MHP
  • Note
    Research use only, not for human use.
  • Brief Description
    MHP is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
  • Description
    Defensamide, also known as MHP and methyl caprooyl tyrosinate, is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
  • In Vitro
    MHP (50-250 μM for 24 hours) increases CAMP mRNA levels in keratinocytes.MHP (100 μM for 24 hours) increases CAMP protein levels in keratinocytes. TCell Viability Assay Cell Line:Keratinocytes Concentration:100 μM Incubation Time:24 hours Result:Increased CAMP protein levels in keratinocytes.
  • In Vivo
    ——
  • Synonyms
    Defensamide | methyl caprooyl tyrosinate | MHP
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    SphK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1104874-94-3
  • Formula Weight
    293.36
  • Molecular Formula
    C16H23NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL 340.88 mM; H2O : < 0.1 mg/mL
  • SMILES
    Oc1ccc(C[C@H](NC(=O)CCCCC)C(=O)OC)cc1
  • Chemical Name
    (S)-Methyl 2-(hexanamido)-3-(4-hydroxyphenyl)propanoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jeong SK, et al. Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. J Dermatol Sci. 2015 Sep;79(3):229-34.
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