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RMC-4550
CAS No. 2172651-73-7
RMC-4550 ( —— )
Catalog No. M26806 CAS No. 2172651-73-7
RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | Get Quote |
|
| 10MG | 178 | Get Quote |
|
| 25MG | 410 | Get Quote |
|
| 50MG | 605 | Get Quote |
|
| 100MG | 860 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameRMC-4550
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NoteResearch use only, not for human use.
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Brief DescriptionRMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).
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DescriptionRMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).(In Vitro):RMC-4550 stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide but lacks activity against the free catalytic domain of SHP2 .(In Vivo):RMC-4550 has moderate to high bioavailability and has a half-life amenable for once daily oral administration. In the EGFR-driven KYSE-520 human esophageal cancer xenograft model, RMC-4550 has a dose dependent efficacy consistent with target modulation, assessed by phospho-ERK inhibition in tumors. RMC-4550 is well tolerated at doses that achieved maximal and sustained efficacy in this model.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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RecptorS. aureus
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Research Area——
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Indication——
Chemical Information
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CAS Number2172651-73-7
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Formula Weight437.4
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Molecular FormulaC21H26Cl2N4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jian-Ming, Shi-Chang, Sun, et al. Isovalerylshikonin, a new resistance-modifying agent from Arnebia euchroma, supresses antibiotic resistance of drug-resistant Staphylococcus aureus.[J]. International journal of antimicrobial agents, 2018.
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