MC4033

CAS No. 28532-21-0

MC4033( —— )

Catalog No. M37143 CAS No. 28532-21-0

MC4033 is a selective lysine acetyltransferase 8 (KAT8) inhibitor (IC50: 12.1 μM) with anticancer effects, induces apoptosis, and can be used for the study of non-small cell lung cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 47 Get Quote
5MG 67 Get Quote
10MG 107 Get Quote
25MG 211 Get Quote
50MG 342 Get Quote
100MG 536 Get Quote
500MG 1125 Get Quote
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Biological Information

  • Product Name
    MC4033
  • Note
    Research use only, not for human use.
  • Brief Description
    MC4033 is a selective lysine acetyltransferase 8 (KAT8) inhibitor (IC50: 12.1 μM) with anticancer effects, induces apoptosis, and can be used for the study of non-small cell lung cancer.
  • Description
    MC4033 shows IC50s of 39.4 μM, 52.1 μM, 41 μM and 30.1 μM in HCT116, H1299, A549 and U937, respectively.MC4033 (25, 50, 100, and 200 μM, 72 h) reduces the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells.
  • In Vitro
    Cell Proliferation AssayCell Line:HT29, HCT116, HeLa, H1299, A549, H460, MCF7, U937, and U251 cellsConcentration:10, 25, 50, and 100 μMIncubation Time:72 hResult:Displayed dose-dependent antiproliferative effects in HCT116, H1299, A549, and U937 cell lines.The inhibition rate of cell proliferation was 70% at 50 μM and >80% at 100 μM in U937 cells.Cell Cycle AnalysisCell Line:HT29, HCT116, and HeLa cells Concentration:50 μM and 100 μM Incubation Time:72 h Result:Propidium iodide (PI) staining showed a slight increase in the percentage of cells with DNA hypodiploid peak, indicative of apoptosis.RT-PCR Cell Line:HCT116 cells Concentration: 100 μM Incubation Time:48h Result:Reduced the mRNA levels of oncogenes UCP2. Immunofluorescence Cell Line: HT29 cells Concentration:50 μM Incubation Time:24 h Result:Reduced H4K16Ac signal intensity by 80%.Western Blot Analysis Cell Line:HCT116 cells Concentration:0,10, 25, 50,100 μM Incubation Time:48 h Result:Showed that the altered ratio of LC3-II/-I and the regulation of p62 autophagy markers indicated the activation of autophagy in HCT116 cells.Apoptosis Analysis Cell Line:HCT116 cells Concentration:100 μM or 10 μM (MC4033/CQ) Incubation Time:72 h Result:Showed that exposure of HCT116 cells to CQ increased the apoptotic effect of KAT8i.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis | Histone Acetyltransferase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    28532-21-0
  • Formula Weight
    295.29
  • Molecular Formula
    C16H13N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (84.66 mM; Ultrasonic )
  • SMILES
    O=C(O)C1=CC=C(C=C1)N2N=C(C(=CC3=CC=CN3)C2=O)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fiorentino F, et al. First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8. J Med Chem. 2023 May 25;66(10):6591-6616?
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