MAP4K4-IN-37

Research use only, not for human use.

MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM.

MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM; inhibits the other kinase family members, MINK and TNIK (IC50 of 1.3 and <0.6 nM); possesses a high degree of kinome selectivity against a set of 244 kinases; shows potent cellular potency with IC50 of 222 nM, exhibits substantial suppression of TNFα release on LPS-induced TNFα levels in male C57-BL/6J mice.

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MAPK/ERK Signaling

MAP4K

MAP4K

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2089334-01-8

382.844

C21H19ClN2O3

>98% (HPLC)

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2-{4-[6-Amino-5-(4-chlorophenyl)pyridin-3-yl]phenoxy}-2-methylpropanoic acid

(-20℃)

With Ice Pack

≥ 2 years