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M4284

CAS No. 1373346-85-0

M4284 ( M-4284;M 4284 )

Catalog No. M11539 CAS No. 1373346-85-0

M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    M4284
  • Note
    Research use only, not for human use.
  • Brief Description
    M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.
  • Description
    M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay; reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota; reduces UTI89 levels in the gut and urinary tracts of mice.
  • Synonyms
    M-4284;M 4284
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    1373346-85-0
  • Formula Weight
    460.48
  • Molecular Formula
    C23H28N2O8
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=C(C=CC(=C1)C2=CC(=CC(=C2)C(=O)NC)C(=O)NC)OC3C(C(C(C(O3)CO)O)O)O
  • Chemical Name
    N3,N5,3'-trimethyl-4'-(((3S,4R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-[1,1'-biphenyl]-3,5-dicarboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Spaulding CN, et al. Nature. 2017 Jun 22;546(7659):528-532.
2. Jarvis C, et al. ChemMedChem. 2016 Feb 17;11(4):367-73.
3. Han Z, et al. J Med Chem. 2012 Apr 26;55(8):3945-59.
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