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M4284
CAS No. 1373346-85-0
M4284 ( M-4284;M 4284 )
Catalog No. M11539 CAS No. 1373346-85-0
M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 255 | Get Quote |
|
| 10MG | 410 | Get Quote |
|
| 25MG | 678 | Get Quote |
|
| 50MG | 954 | Get Quote |
|
| 100MG | 1287 | Get Quote |
|
| 500MG | 2574 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameM4284
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NoteResearch use only, not for human use.
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Brief DescriptionM4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.
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DescriptionM4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay; reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota; reduces UTI89 levels in the gut and urinary tracts of mice.
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SynonymsM-4284;M 4284
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number1373346-85-0
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Formula Weight460.48
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Molecular FormulaC23H28N2O8
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C(C=CC(=C1)C2=CC(=CC(=C2)C(=O)NC)C(=O)NC)OC3C(C(C(C(O3)CO)O)O)O
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Chemical NameN3,N5,3'-trimethyl-4'-(((3S,4R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-[1,1'-biphenyl]-3,5-dicarboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Spaulding CN, et al. Nature. 2017 Jun 22;546(7659):528-532.
2. Jarvis C, et al. ChemMedChem. 2016 Feb 17;11(4):367-73.
3. Han Z, et al. J Med Chem. 2012 Apr 26;55(8):3945-59.
2. Jarvis C, et al. ChemMedChem. 2016 Feb 17;11(4):367-73.
3. Han Z, et al. J Med Chem. 2012 Apr 26;55(8):3945-59.
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