Antagonist G( ——— )

Catalog No. M41872 CAS No. 115150-59-9

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Product Name

Antagonist G
Note

Research use only, not for human use.
Brief Description

Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy.
Description

Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.
In Vitro

Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells.Antagonist G activates JNK1 in SCLC cells.Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%.Cell Viability Assay Cell Line:SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells.Concentration:0-100 μM.Incubation Time:24 h.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

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Research Area

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Indication

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1. P J Woll, et al. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 1990 Jul 1;50(13):3968-73.?

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