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Antagonist G
CAS No. 115150-59-9
Antagonist G( ——— )
Catalog No. M41872 CAS No. 115150-59-9
Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 229 | In Stock |
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| 10MG | 371 | In Stock |
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| 25MG | Get Quote | In Stock |
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| 50MG | Get Quote | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAntagonist G
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NoteResearch use only, not for human use.
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Brief DescriptionAntagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy.
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DescriptionAntagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.
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In VitroAntagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells.Antagonist G activates JNK1 in SCLC cells.Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%.Cell Viability Assay Cell Line:SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells.Concentration:0-100 μM.Incubation Time:24 h.
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptor———
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Research Area———
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Indication———
Chemical Information
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CAS Number115150-59-9
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Formula Weight951.2
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Molecular FormulaC49H62O6N12S
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Purity>98% (HPLC)
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SolubilityH2O : 50 mg/mL (52.57 mM; ultraphonic)
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. P J Woll, et al. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 1990 Jul 1;50(13):3968-73.?
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