BRD-K98645985( ——— )

Catalog No. M39451 CAS No. 1357647-78-9

BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 μM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity.

Purity : >98% (HPLC)

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Biological Information

Product Name

BRD-K98645985
Note

Research use only, not for human use.
Brief Description

BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 μM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity.
Description

BRD-K98645985 is a BAF transcriptional repression inhibitor (EC50: ~2.37 μM). It binds ARID1A-specific BAF complexes, potently reverses HIV-1 latency and prevents nucleosomal positioning.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

HIV-1;BAF transcriptional repression
Research Area

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Indication

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Chemical Information

CAS Number

1357647-78-9
Formula Weight

573.73
Molecular Formula

C33H43N5O4
Purity

>98% (HPLC)
Solubility

DMSO : 250 mg/mL (435.75 mM; ultraphonic; )
SMILES

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Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Marian CA, et al. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14.?

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