BRD-K98645985

CAS No. 1357647-78-9

BRD-K98645985( ——— )

Catalog No. M39451 CAS No. 1357647-78-9

BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 μM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BRD-K98645985
  • Note
    Research use only, not for human use.
  • Brief Description
    BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 μM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity.
  • Description
    BRD-K98645985 is a BAF transcriptional repression inhibitor (EC50: ~2.37 μM). It binds ARID1A-specific BAF complexes, potently reverses HIV-1 latency and prevents nucleosomal positioning.
  • In Vitro
    ———
  • In Vivo
    ———
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    HIV-1;BAF transcriptional repression
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    1357647-78-9
  • Formula Weight
    573.73
  • Molecular Formula
    C33H43N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 250 mg/mL (435.75 mM; ultraphonic; )
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Marian CA, et al. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14.?
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