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[D-Trp11]-Neurotensin
CAS No. 73634-68-1
[D-Trp11]-Neurotensin( ——— )
Catalog No. M41742 CAS No. 73634-68-1
[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name[D-Trp11]-Neurotensin
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NoteResearch use only, not for human use.
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Brief Description[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension.
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Description[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension.
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In Vitro[D-Trp11]-Neurotensin (0.13-1.1 μM) markedly inhibits NT-induced coronary vessel constriction in perfused rat hearts.[D-Trp11]-Neurotensin (2-110 μM) exhibits NT-like activity in perfused rat hearts.
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In Vivo[D-Trp11]-Neurotensin (50-500 nmol/kg; i.v.) has hypotensive activity in pentobarbital-anesthetized rats, with an ED25 of 122 nmol/kg.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorNeurotensin Receptor
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Research Area———
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Indication———
Chemical Information
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CAS Number73634-68-1
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Formula Weight1696
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Molecular FormulaC80H122N22O19
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Quirion R, et, al. Selective blockade of neurotensin-induced coronary vessel constriction in perfused rat hearts by a neurotensin analogue. Eur J Pharmacol. 1980 Feb 8;61(3):309-12.?
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