[D-Pro2,D-Phe7,D-Trp9]-Substance P( ——— )

Catalog No. M41635 CAS No. 77275-70-8

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MSDS

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Product Name

[D-Pro2,D-Phe7,D-Trp9]-Substance P
Note

Research use only, not for human use.
Brief Description

[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly.
Description

[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly.
In Vitro

[D-Pro2,D-Phe7,D-Trp9] Substance P (10-100 μM; 2 min or 10 min) produces dose-related contractions of the guinea-pig ileum and in the rabbit external jugular vein.
In Vivo

[D-Pro2,D-Phe7,D-Trp9] Substance P (1-2 mg/kg; i.v.; once) inhibits the salivary secretion which was induced by Substance P in rats. In the dosage range at 1-1.5 mg/kg slightly increases the blood pressure.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Substance P
Research Area

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Indication

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1. Hawcock AB, et al. Agonist effects of D-Pro2,D-Phe7,D-Trp9substance P--evidence for different receptors. Eur J Pharmacol. 1982 May 7;80(1):135-8.?

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