Angiotensinogen (1- 13)

Aminomalonic acid (Ama) was first detected in alkaline hydrolysates of proteins in 1984. Ama has been isolated from proteins of Escherichia coli and human atherosclerotic plaque. The presence of Ama has important biological implications because the malonic acid moiety potentially imparts calcium binding properties to protein.

Edetic acid is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.