Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions by reducing hyperpolarizations. Acts as a functional antagonist of inflammatory mediators.

Coumaperine, a product found in white pepper, is also a 5-LOX inhibitor with potential anti-inflammatory and anti-cancer activity and can be used to study inflammatory diseases caused by bacterial infections.

Jionoside B1 has immunosuppressive activity and shows the hepato-protective activity in the H2O2 induced liver injury experiments.