Imipramine (hydrochloride) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM respectively).

Substance P (4-11), the C-terminus fragment of Substance P (Substance P ), is a Substance P agonist that shows highly selective for NK1 receptors.

Buddlejasaponin IVb(200 uM) can shorten thrombin time (TT) by 20.6 %, suggests that it has hemostasis efficacy.