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α-Conotoxin EI
CAS No. 170663-33-9
α-Conotoxin EI( ——— )
Catalog No. M41034 CAS No. 170663-33-9
α-Conotoxin EI is a selective nicotinic acetylcholine α1β1γδ receptor (nAChR) antagonist (IC50=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Nameα-Conotoxin EI
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NoteResearch use only, not for human use.
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Brief Descriptionα-Conotoxin EI is a selective nicotinic acetylcholine α1β1γδ receptor (nAChR) antagonist (IC50=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors.
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DescriptionSelective antagonist of neuromuscular nicotinic receptors α1β1γδ
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In Vitroα-Conotoxin EI (10 μM) blocks muscle and ganglionic receptors, but less potent for the central nevous system receptor.α-Conotoxin EI (10 μM) blocks the α1β1γδ receptors with a τon of 4.9 s, and blocks the α3β4 receptor with a τon of 11 s.
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In Vivoα-Conotoxin EI (intraperitoneal injection) into mice induces muscular weakness, followed by flaccid paralysis and ultimately death.
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Synonyms———
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PathwayEndocrinology/Hormones
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TargetAChR
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Recptorneuromuscular nicotinic receptors α1β1γδ
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Research Area———
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Indication———
Chemical Information
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CAS Number170663-33-9
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Formula Weight2093.37
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Molecular FormulaC83H125N27O27S5
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Martinez JS, et al. alpha-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry. 1995 Nov 7;34(44):14519-26.?
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