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α-Conotoxin EI

CAS No. 170663-33-9

α-Conotoxin EI( ——— )

Catalog No. M41034 CAS No. 170663-33-9

α-Conotoxin EI is a selective nicotinic acetylcholine α1β1γδ receptor (nAChR) antagonist (IC50=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    α-Conotoxin EI
  • Note
    Research use only, not for human use.
  • Brief Description
    α-Conotoxin EI is a selective nicotinic acetylcholine α1β1γδ receptor (nAChR) antagonist (IC50=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors.
  • Description
    Selective antagonist of neuromuscular nicotinic receptors α1β1γδ
  • In Vitro
    α-Conotoxin EI (10 μM) blocks muscle and ganglionic receptors, but less potent for the central nevous system receptor.α-Conotoxin EI (10 μM) blocks the α1β1γδ receptors with a τon of 4.9 s, and blocks the α3β4 receptor with a τon of 11 s.
  • In Vivo
    α-Conotoxin EI (intraperitoneal injection) into mice induces muscular weakness, followed by flaccid paralysis and ultimately death.
  • Synonyms
    ———
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    neuromuscular nicotinic receptors α1β1γδ
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    170663-33-9
  • Formula Weight
    2093.37
  • Molecular Formula
    C83H125N27O27S5
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Martinez JS, et al. alpha-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry. 1995 Nov 7;34(44):14519-26.?
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