Cortistatin-29 (rat)( ——— )

Catalog No. M40792 CAS No. 1815618-17-7

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Cortistatin-29 (rat)
Note

Research use only, not for human use.
Brief Description

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.
Description

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.
In Vitro

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In Vivo

Animal Model:20-24 g body weight, 8-12 weeks-old mice Dosage:1 μg in 20 μL for s.c.; 2 μg in 200 μL for i.p.; 20 ng in 10 μL for i.t.Administration:Every other day for 12 days Result:Ameliorated hyperalgesia and allodynia, regulated the nerve damageinduced hypersensitization of primary nociceptors, inhibited neuroinflammatory responses, and enhanced the production of neurotrophic factors both at the peripheral and central levels.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

SSTR1: 2.8 nM (IC50), SSTR2: 7.1 nM (IC50), SSTR3: 0.2 nM (IC50), SSTR4: 3.0 nM (IC50), SSTR5: 13.7 nM (IC50)]
Research Area

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Indication

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Chemical Information

CAS Number

1815618-17-7
Formula Weight

3540.09
Molecular Formula

C161H240N46O41S2
Purity

>98% (HPLC)
Solubility

———
SMILES

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Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Falo CP, et al. The Neuropeptide Cortistatin Alleviates Neuropathic Pain in Experimental Models of Peripheral Nerve Injury. Pharmaceutics. 2021 Jun 24;13(7):947.?

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