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Cortistatin-29 (rat)
CAS No. 1815618-17-7
Cortistatin-29 (rat)( ——— )
Catalog No. M40792 CAS No. 1815618-17-7
Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCortistatin-29 (rat)
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NoteResearch use only, not for human use.
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Brief DescriptionCortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.
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DescriptionCortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.
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In Vitro———
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In VivoAnimal Model:20-24 g body weight, 8-12 weeks-old mice Dosage:1 μg in 20 μL for s.c.; 2 μg in 200 μL for i.p.; 20 ng in 10 μL for i.t.Administration:Every other day for 12 days Result:Ameliorated hyperalgesia and allodynia, regulated the nerve damageinduced hypersensitization of primary nociceptors, inhibited neuroinflammatory responses, and enhanced the production of neurotrophic factors both at the peripheral and central levels.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorSSTR1: 2.8 nM (IC50), SSTR2: 7.1 nM (IC50), SSTR3: 0.2 nM (IC50), SSTR4: 3.0 nM (IC50), SSTR5: 13.7 nM (IC50)]
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Research Area———
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Indication———
Chemical Information
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CAS Number1815618-17-7
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Formula Weight3540.09
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Molecular FormulaC161H240N46O41S2
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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