CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM, demonstrating significant proliferation inhibitory activity against various cancer cell lines in vitro.

HIV-IN-11 is part of the hydroxylaminoglutaramide (HAPA) transition state isomeric series of HIV protease inhibitors and is a potent and selective inhibitor of HIV-1 protease. HIV-IN-11 competitively inhibits HIV-1 PR (Ki: 0.049 nM) and potently inhibits replication of HIV(IIIb)-infected MT4 lymphocytes at concentrations of 25.0-50.0 nM. HIV-IN-11 displays a longer half-life than indinavir sulfate in animal models and serves as a promising second-generation HIV protease inhibitor.

hRIO2 kinase ligand-1 is a potent ligand for hRIO2 kinase (Kd: 520 nM).