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Neuropeptide Y (18-36)
CAS No. 114495-97-5
Neuropeptide Y (18-36)( ——— )
Catalog No. M40291 CAS No. 114495-97-5
Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameNeuropeptide Y (18-36)
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NoteResearch use only, not for human use.
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Brief DescriptionNeuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure.
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DescriptionNeuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist.
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In VitroNeuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM.Neuropeptide Y (18-36) (porcine) (1 μM) shifts the inhibitory adenylate cyclase activity dose-response curve of NPY to the right in a parallel fashion.Neuropeptide Y (18-36) (porcine) (1 μM) completely abolishes the effect of NPY (10 nM) that alone caused 80% of the maximum inhibition of adenylate cyclase activity.
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorIC50: 158 nM (I-NPY); Ki: 140 nM (I-NPY)
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Research Area———
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Indication———
Chemical Information
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CAS Number114495-97-5
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Formula Weight3000.5
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Molecular FormulaC134H207N41O36S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL (40.70 mM; )
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. A Balasubramaniam, et al. Neuropeptide Y (18-36) is a competitive antagonist of neuropeptide Y in rat cardiac ventricular membranes. J Biol Chem. 1990 Sep 5;265(25):14724-7. ?
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