(Glu2)-TRH( ——— )

Catalog No. M40243 CAS No. 85541-78-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

(Glu2)-TRH
Note

Research use only, not for human use.
Brief Description

(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS.
Description

(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS.
In Vitro

———
In Vivo

Animal Model:Male Swiss-Webster mice (30 g)Dosage:1, 2, 5, 10, 15, 25, 50, 100 μmol/kg Administration:IV; 10 min before Pentobarbital (60 mg/kg, i.p.) Result:Dose-dependently attenuated TRH-induced (10 μmol/kg; iv) analeptic action.
Synonyms

———
Pathway

Others
Target

Other Targets
Recptor

———
Research Area

———
Indication

———

1. Vien Nguyen, et al. Glu2TRH dose-dependently attenuates TRH-evoked analeptic effect in mice. Brain Res Bull. 2010 Apr 29;82(1-2):83-6.?

Calculator

molnova catalog