Acetyl-Hirudin (54-65) (sulfated) is a acetyl-fragment of Hirudin which binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex.

Trigonelline, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.

Extracted from Honey,fruits,berries,melon.