Butin

Research use only, not for human use.

Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera with oral activity, with strong antioxidant, antiplatelet and anti-inflammatory activities. Butin significantly alleviates myocardial infarction and improves heart function, together with prevents diabetes-induced cardiac oxidative damage in rat.

Butin, a major biologically active flavonoid isolated from the Dalbergia odorifera, has strong antioxidant, anti-inflammatory and antiplatelet activities.

Cell Viability Assay Cell Line:H9c2 Concentration:12.5, 25, 50 μM Incubation Time:6 h Result:Increased cell survival in a dose-dependent manner.Western Blot Analysis Cell Line:H9c2 Concentration:12.5, 25, 50 μM Incubation Time:6 h Result: Increased the expression of GSH-px, GSH, SOD, CAT and HO-1.Real Time qPCR Cell Line:H9c2 Concentration:12.5, 25, 50 μM Incubation Time:6 h Result:Increased the levels of Nrf2 in the cytoplasm and nucleus in a dose-dependent manner and enhanced the expressions of GSH-px, GSH, SOD, CAT and HO-1.

Animal Model:C57/BL6J mice induced by STZ Dosage:10, 20, 40 mg/kg; twice a day; 15 days Administration:OralResult:Improved cardiac function, significant increases in LVSP, +dP/dtmax and -dP/dtmin, reduced myocardial infarction area, reduced caspase-3 activity and Bax/Bcl-2 ratio, reduced GSH-px, GSH, SOD, CAT and GR activity.Animal Model:Intracerebral hemorrhage rats Dosage:25, 50 mg/kg; single dose Administration:Intraperitoneal injection (i.p.)Result:Increased the neurological score, significantly reduced the volume of hemorrhagic lesions, significantly reduced the Bax/Bcl-2 ratio and caspase-3 protein expression, and significantly reduced brain tissue inflammatory mediators tumor necrosis factor-α (TNF-α) and interleukin. Reduced levels of 6 (IL-6).

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Others

Other Targets

Others

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21913-99-5

272.25

C15H12O5

>98% (HPLC)

DMSO : 100 mg/mL (367.30 mM; ultraphonic; )

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(-20℃)

With Ice Pack

≥ 2 years