Nigranoic acid

Research use only, not for human use.

Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.

Nigranoic acid is a natural product,and inhibits HIV-1 reverse transcriptase.

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Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation. Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.Animal Model:Sprague–Dawley rats (200-300 g), ischemia–reperfusion model Dosage:1 mg/kg Administration:Intragastric; 6 hours and 2 hours before brain ischemia Result:Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.

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Others

Other Targets

HIV-1 reverse transcriptase

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39111-07-4

470.68

C30H46O4

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years