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Nigranoic acid
CAS No. 39111-07-4
Nigranoic acid( ——— )
Catalog No. M39372 CAS No. 39111-07-4
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 50MG | Get Quote | In Stock |
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Biological Information
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Product NameNigranoic acid
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NoteResearch use only, not for human use.
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Brief DescriptionNigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.
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DescriptionNigranoic acid is a natural product,and inhibits HIV-1 reverse transcriptase.
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In Vitro———
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In VivoNigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation. Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.Animal Model:Sprague–Dawley rats (200-300 g), ischemia–reperfusion model Dosage:1 mg/kg Administration:Intragastric; 6 hours and 2 hours before brain ischemia Result:Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorHIV-1 reverse transcriptase
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Research Area———
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Indication———
Chemical Information
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CAS Number39111-07-4
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Formula Weight470.68
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Molecular FormulaC30H46O4
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sun HD, et al. Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase. J Nat Prod. 1996 May;59(5):525-7.?
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