4,5-dehydroisopsoralidin( ——— )

Catalog No. M38999 CAS No. 65639-51-2

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Product Name

4,5-dehydroisopsoralidin
Note

Research use only, not for human use.
Brief Description

4'',5''-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC50: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners.
Description

4",5"-dehydroisopsoralidin is a natural product.
In Vitro

4'',5''-Dehydroisopsoralidin (compound 5, 15 min) inhibits the release of β-glucuronidase in polymorphonuclear leukocytes (PMNs) of rats, with an IC50 value of 6.3 μM.4'',5''-Dehydroisopsoralidin (compound 9, 24 h) shows weak cytotoxicity (IC50: >50 μM) to H4IIE, HCT116, C6 cells.4'',5''-Dehydroisopsoralidin (25 μM, 1h) causes significant radical scavenging in H4IIE rat hepatoma cells (TEAC assay).4'',5''-Dehydroisopsoralidin (compound 5, 15 μM, 60 h) increases lifespan in P. corylifolia (MEP assay).
In Vivo

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Pathway

Others
Target

Other Targets
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Research Area

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Indication

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1. De-Wu Zhang, et al. Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum. J Nat Med. 2012 Apr;66(2):362-6. ?

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