2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)

Research use only, not for human use.

2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist.

2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist.(In Vitro):2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is equally effective to and 10 to 25 times more potent than SLIGRLNH2 for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively. In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is 10 to 300 times more potent than SLIGRL-NH2. Unlike trans-cinnamoyl-LIGRLO-NH2, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries.

——

——

——

Others

Other Targets

Proteise-activated receptor 2 (PAR2)

——

——

——

——

——

>98% (HPLC)

——

——

Sequence:{Fur-2-oyl}-Leu-Ile-Gly-Arg-Leu-{Orn}-NH2

(-20℃)

With Ice Pack

≥ 2 years