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Saikogenin D

CAS No. 5573-16-0

Saikogenin D( ——— )

Catalog No. M38805 CAS No. 5573-16-0

Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Saikogenin D
  • Note
    Research use only, not for human use.
  • Brief Description
    Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores.
  • Description
    Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellular stores.
  • In Vitro
    Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells.Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells.
  • In Vivo
    ———
  • Synonyms
    ———
  • Pathway
    GPCR/G Protein
  • Target
    Prostaglandin Receptor
  • Recptor
    PGE;Calcium Channel;IL Receptor
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    5573-16-0
  • Formula Weight
    472.7
  • Molecular Formula
    C30H48O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL (211.55 mM; )
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Toriniwa Y, et al. Participation of epoxygenase activation in saikogenin D-induced?inhibition?of prostaglandin E(2) synthesis.J Pharm Pharmacol.?2006 Jun;58(6):859-66.?
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