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Saikogenin D
CAS No. 5573-16-0
Saikogenin D( ——— )
Catalog No. M38805 CAS No. 5573-16-0
Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 227 | In Stock |
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| 10MG | 337 | In Stock |
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| 25MG | 559 | In Stock |
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| 50MG | 779 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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Biological Information
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Product NameSaikogenin D
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NoteResearch use only, not for human use.
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Brief DescriptionSaikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores.
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DescriptionSaikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellular stores.
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In VitroSaikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells.Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells.
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In Vivo———
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Synonyms———
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PathwayGPCR/G Protein
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TargetProstaglandin Receptor
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RecptorPGE;Calcium Channel;IL Receptor
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Research Area———
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Indication———
Chemical Information
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CAS Number5573-16-0
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Formula Weight472.7
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Molecular FormulaC30H48O4
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL (211.55 mM; )
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Toriniwa Y, et al. Participation of epoxygenase activation in saikogenin D-induced?inhibition?of prostaglandin E(2) synthesis.J Pharm Pharmacol.?2006 Jun;58(6):859-66.?
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