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BMY 45778
CAS No. 152575-66-1
BMY 45778( BMY-45778 | BMY45778 )
Catalog No. M12132 CAS No. 152575-66-1
A potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameBMY 45778
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation.
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DescriptionA potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation; activates adenylyl cyclase (ED50=6-10 nM) and stimulates GTPase in human platelet membrane preparations; prevents [3H]]Iloprost binding to platelet membranes with IC50 of 7 nM, causes elevation of platelet cAMP levels (cAMP content doubles at 13 nM) and activation of the cAMP-dependent protein kinase in whole platelets. Dyslipidemia Discontinued.
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In Vitro——
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In Vivo——
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SynonymsBMY-45778 | BMY45778
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PathwayGPCR/G Protein
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TargetProstaglandin Receptor
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RecptorProstaglandin Receptor
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Research AreaCardiovascular Disease
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IndicationDyslipidemia
Chemical Information
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CAS Number152575-66-1
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Formula Weight438.44
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Molecular FormulaC26H18N2O5
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)COC1=CC=CC(C2=C(C3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)N=CO2)=C1
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Chemical Name[3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]acetic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Meanwell NA, et al. J Med Chem. 1993 Nov 26;36(24):3884-903.
2. Seiler SM, et al. Prostaglandins. 1997 Jan;53(1):21-35.
3. Rudd JA, et al. Br J Pharmacol. 2000 Feb;129(4):782-90.
4. Chow KB, et al. Br J Pharmacol. 2001 Dec;134(7):1375-84.
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