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Home - Products - GPCR/G Protein - Prostaglandin Receptor - BMY 45778

BMY 45778

CAS No. 152575-66-1

BMY 45778( BMY-45778 | BMY45778 )

Catalog No. M12132 CAS No. 152575-66-1

A potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BMY 45778
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation.
  • Description
    A potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation; activates adenylyl cyclase (ED50=6-10 nM) and stimulates GTPase in human platelet membrane preparations; prevents [3H]]Iloprost binding to platelet membranes with IC50 of 7 nM, causes elevation of platelet cAMP levels (cAMP content doubles at 13 nM) and activation of the cAMP-dependent protein kinase in whole platelets. Dyslipidemia Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BMY-45778 | BMY45778
  • Pathway
    GPCR/G Protein
  • Target
    Prostaglandin Receptor
  • Recptor
    Prostaglandin Receptor
  • Research Area
    Cardiovascular Disease
  • Indication
    Dyslipidemia

Chemical Information

  • CAS Number
    152575-66-1
  • Formula Weight
    438.44
  • Molecular Formula
    C26H18N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)COC1=CC=CC(C2=C(C3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)N=CO2)=C1
  • Chemical Name
    [3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Meanwell NA, et al. J Med Chem. 1993 Nov 26;36(24):3884-903. 2. Seiler SM, et al. Prostaglandins. 1997 Jan;53(1):21-35. 3. Rudd JA, et al. Br J Pharmacol. 2000 Feb;129(4):782-90. 4. Chow KB, et al. Br J Pharmacol. 2001 Dec;134(7):1375-84.
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