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Aflatoxin B1
CAS No. 1162-65-8
Aflatoxin B1( ——— )
Catalog No. M38785 CAS No. 1162-65-8
Aflatoxin B1 (AFB1) is a Group 1A carcinogen and a secondary metabolite produced by Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) primarily induces mutations by causing a G to T transversion at the third nucleotide of codon 249 in the tumor suppressor gene p53. In the body, Aflatoxin B1 (AFB1) can cause damage to the intestines and kidneys and has some teratogenic effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameAflatoxin B1
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NoteResearch use only, not for human use.
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Brief DescriptionAflatoxin B1 (AFB1) is a Group 1A carcinogen and a secondary metabolite produced by Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) primarily induces mutations by causing a G to T transversion at the third nucleotide of codon 249 in the tumor suppressor gene p53. In the body, Aflatoxin B1 (AFB1) can cause damage to the intestines and kidneys and has some teratogenic effects.
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DescriptionAflatoxin B1 (AFB1) is a Class 1A carcinogen. It is a secondary metabolite of Aspergillus flavus and A. parasiticus.
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In VitroCell Cytotoxicity Assay Cell Line:Differentiated and undifferentiated Caco-2 cells Concentration:0, 0.01, 0.05, 0.1, 0.5 and 1 μg/mL Incubation Time:24, 48 and 72 h Result:Cytotoxicity was dose-dependent at doses of 0.05-1 μg/mL, and increased cell death in both differentiated and undifferentiated cells at concentrations of 0.5 μg/mL and above.Cell Cytotoxicity Assay Cell Line:HEK 293 cells Concentration:0, 5, 10, 50, 100 and 200 mg/L Incubation Time:48 h Result:Upregulated the expression levels of proline dehydrogenase (PRODH) and pro-apoptotic factors (Bax, Caspase-3), and downregulated the expression of apoptosis inhibitor Bcl-2.
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In VivoAnimal Model:35-day subacute toxicity CD-1 mice model Dosage:0.5 mg/kg Administration:i.g.Result:Caused edema and cell proliferation in some parts, occasionally severe inflammatory cell infiltration and bleeding.Animal Model:New Zealand White female rabbits Dosage:0.025, 0.05 and 0.1 mg/kg Administration:i.g.; give during days 6-18 of pregnancy Result:At doses of 0.025, 0.05 and 0.1 mg/kg, the incidence of wrist droop and eye socket enlargement in white rabbits was 3.57%, 4.00% and 14.28% respectively.And at a dose of 0.1 mg/kg, a few rabbits developed microphthalmia and heart defects.
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Synonyms———
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorHuman Endogenous Metabolite
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Research Area———
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Indication———
Chemical Information
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CAS Number1162-65-8
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Formula Weight312.281
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Molecular FormulaC17H12O6
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Purity>98% (HPLC)
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SolubilityDMF : 33.33 mg/mL (106.73 mM) DMSO : 30 mg/mL (96.07 mM)
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gizachew D, et al. Aflatoxin B1 (AFB1) production by Aspergillus flavus and Aspergillus parasiticus on ground Nyjer seeds: The effect of water activity and temperature. Int J Food Microbiol. 2019 May 2;296:8-13.?
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