Silybin

Research use only, not for human use.

Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity.

Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity.

Silybin (0-200 mM; for 72 hours) has growth inhibition in a time- and dose-dependent manner. Silybin (68 μM; for 72 hours) induces apoptosis and increases the cells in G1-phase of ~22%. Silybin (68 μM; for 72 hours) induces AKT activity inhibition. Cell Viability Assay Cell Line:HepG2 cell growth Concentration:0-200 mM Incubation Time:For 72 hours Result:Had growth inhibition in a time- and dose-dependent manner with an IC50 of 68 μM.Apoptosis Analysis Cell Line:HepG2 cell growth Concentration: 68 μM；Incubation Time:For 72 hours Result:Induced apoptosis in a higher number of cells (60%) when compared to untreated cells.Cell Cycle Analysis Cell Line:HepG2 cell growth；Concentration:68 μM Incubation Time:For 72 hours Result:Increased the cells in G1-phase of ~22% and decreased of 47% the cells in S-phase.Western Blot Analysis Cell Line:HepG2 cell growth Concentration:68 μM Incubation Time:For 72 hours Result:Induced AKT activity inhibition.

Silybin (50, 100?mg/kg/day; given intragastrically for the last 4 weeks) significantly lowers both serum and hepatic lipid accumulation. Animal Model:Male C57BL/6J mice (6-8 weeks old) with nonalcoholic fatty liver disease (NAFLD)Dosage:50, 100?mg/kg Administration:Given intragastrically; daily; for the last 4 weeks Result:Significantly lowered both serum and hepatic lipid accumulation.

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Others

Other Targets

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802918-57-6

482.44

C25H22O10

>98% (HPLC)

DMSO : 25 mg/mL (51.82 mM; ultraphonic; )

C(O)C1C(OC=2C(O1)=CC=C(C2)[C@H]3OC=4C(C(=O)[C@@H]3O)=C(O)C=C(O)C4)C5=CC(OC)=C(O)C=C5

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(-20℃)

With Ice Pack

≥ 2 years